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Jennifer I. L. Chen, Heather Durkee, Beth Traxler and David S. Ginger Optical Detection of Protein in Complex Media with Plasmonic Nanoparticle Dimers Small 7

Article first published online: 14 JUN 2011 | DOI: 10.1002/smll.201100617

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Actuatable gold nanoparticle dimers for protein sensing are presented. By monitoring the spectral blue shift in the hybridized bonding plasmon mode instead of the conventional refractive index changes on a single nanoparticle, dimers are shown to be able to detect target protein even in the presence of high levels of nonspecific binding in complex media such as serum.

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