Young-Hwa Kim, Jongho Jeon, Su Hyun Hong, Won-Kyu Rhim, Yun-Sang Lee, Hyewon Youn, June-Key Chung, Myung Chul Lee, Dong Soo Lee, Keon Wook Kang and Jwa-Min Nam Tumor Targeting and Imaging Using Cyclic RGD-PEGylated Gold Nanoparticle Probes with Directly Conjugated Iodine-125 Small 7
Highly stable and tumor-specific SPECT/CT imaging nanoparticle probes are described. Cyclic RGD-PEGlyated gold nanoparticle probes with directly conjugated iodine-125 can specifically target αvβ3 integrin-expressing tumor cells and can be taken up by tumor cells via integrin αvβ3-receptor-mediated endocytosis with almost no cytotoxicity. The probes can target tumor sites in vivo only 10 min after intravenous injection. These probes can be excreted after tumor targeting.
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