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Yu Zhou, Kun Li, Jia Yuan Yang, Chen Xi Guan, Ying Wang, Chang Jian Liu and Jian Hua Zhu Small-Caliber Vascular Prosthesis Prototype Based on Controlled Release of Heparin from Mesochannels and Its Enhanced Biocompatibility Small 8

Version of Record online: 29 FEB 2012 | DOI: 10.1002/smll.201101270

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A vascular prosthesis prototype is prepared by directly modifying expanded polytetrafluoroethylene (ePTFE) grafts with mesochannels through in situ epitaxial growth of mesoporous silica nanoparticles on ePTFE grafts. Slow and sustained release of heparin from the mesochannels is achieved, and thrombin is inactivated by antithrombin III (AT III). The performance of artificial blood vessels is thus improved.

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