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Christina J. Newcomb, Ronit Bitton, Yuri S. Velichko, Malcolm L. Snead and Samuel I. Stupp The Role of Nanoscale Architecture in Supramolecular Templating of Biomimetic Hydroxyapatite Mineralization Small 8

Article first published online: 8 MAY 2012 | DOI: 10.1002/smll.201102150

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Hierarchical mineralization of hydroxyapatite using supramolecular templates: Peptide amphiphile molecules with different nanoscale morphologies are mineralized with hydroxyapatite. The ability to nucleate oriented hydroxyapatite is observed to be dependent on the template geometry and is recapitulated at higher length scales to form hierarchical organic–inorganic hybrid materials mimetic of cortical bone. These constructs have potential for studying the role of alignment in cell signaling and could be prepared into therapeutic scaffolds for regeneration of mineralized tissue.

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