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Siyuan Han, Yuexian Liu, Xin Nie, Qing Xu, Fang Jiao, Wei Li, Yuliang Zhao, Yan Wu and Chunying Chen Efficient Delivery of Antitumor Drug to the Nuclei of Tumor Cells by Amphiphilic Biodegradable Poly(L-Aspartic Acid-co-Lactic Acid)/DPPE Co-Polymer Nanoparticles Small 8

Article first published online: 13 MAR 2012 | DOI: 10.1002/smll.201102280

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A novel amphiphilic biodegradable poly(aspartic acid (AA)-co-lactic acid (LA))/DPPE co-polymer is synthesized and used to prepare doxorubicin (DOX)-loaded nanoparticles for tumor therapy. These nanoparticles are prepared by double emulsion method and exhibit pH-responsive drug release profiles. It is of great interest that these poly(AA-co-LA)/DPPE nanoparticles can efficiently deliver a chemotherapy drug DOX into the nuclei specifically within tumor cells and show dose- and time-dependent cytotoxicity.

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