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Sébastien Deshayes, Karidia Konate, Anna Rydström, Laurence Crombez, Cédric Godefroy, Pierre-Emmanuel Milhiet, Annick Thomas, Robert Brasseur, Gudrun Aldrian, Frédéric Heitz, Maria A. Muñoz-Morris, Jean-Marie Devoisselle and Gilles Divita Self-Assembling Peptide-Based Nanoparticles for siRNA Delivery in Primary Cell Lines Small 8

Version of Record online: 18 APR 2012 | DOI: 10.1002/smll.201102413

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The secondary amphipathic peptide CADY forms stable positively charged nanoparticles with short interfering RNA (siRNA), which involves both electrostatic and hydrophobic interactions. CADY/siRNA self-assembling nanoparticles adopt a “raspberry”-like architecture cemented together by a matrix of free peptides. These nanoparticles are nontoxic and promote efficient delivery of siRNA in challenging primary cell lines.

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