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Ryo Ishibashi, Kazuma Mawatari and Takehiko Kitamori Highly Efficient and Ultra-small Volume Separation by Pressure-Driven Liquid Chromatography in Extended Nanochannels Small 8

Version of Record online: 21 FEB 2012 | DOI: 10.1002/smll.201102420

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Pressure-driven liquid chromatography in a 200 nm deep, open-column channel enables separation of atto- to femtoliter sample volume, with a high separation efficiency of 440 000 plates/m within a few seconds. This high efficiency is due to the small and controlled size of the separation channel where the diffusion through the channel depth direction is fast enough to be neglected.

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