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Anthony J. Di Pasqua, James E. Huckle, Jin-Ki Kim, Younjee Chung, Andrew Z. Wang, Michael Jay and Xiuling Lu Preparation of Neutron-Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases Small 8

Version of Record online: 2 FEB 2012 | DOI: 10.1002/smll.201102488

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Nanoparticles containing stable holmium (165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.

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