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Yoshiaki Maeda, Zengyan Wei and Hiroshi Matsui Biomimetic Assembly of Proteins into Microcapsules on Oil-in-Water Droplets with Structural Reinforcement via Biomolecular-Recognition-Based Cross-Linking of Surface Peptides Small 8

Version of Record online: 29 FEB 2012 | DOI: 10.1002/smll.201102571

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By mimicking the stabilization of bacterial membranes with S-layer proteins, a novel process to fabricate highly stable protein microcapsules is introduced. In this strategy, engineered collagen peptides with site-specific biotinylation are assembled into microcapsules on the oil-in-water droplets, and the resulting microcapsules are reinforced by biomolecular-recognition-based cross-linking with the protein. Furthermore the microcapsules are shown to be versatile scaffolds for developing functionalized hierarchical colloidosomes for important biotechnological applications.

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