James Harrison, Carole A. Bartlett, Gary Cowin, Philip K. Nicholls, Cameron W. Evans, Tristan D. Clemons, Bogdan Zdyrko, Igor A. Luzinov, Alan R. Harvey, K. Swaminathan Iyer, Sarah A. Dunlop and Melinda Fitzgerald In vivo Imaging and Biodistribution of Multimodal Polymeric Nanoparticles Delivered to the Optic Nerve Small 8
Version of Record online: 13 MAR 2012 | DOI: 10.1002/smll.201102648
Whole animal magnetic resonance imaging (MRI) and fluorescence analyses demonstrate that poly(glycidyl methacrylate) (PGMA) nanoparticles coated with polyethylenimine (PEI) and containing an MRI contrast agent (superparamagnetic iron oxide nanoparticles) and fluorophore (rhodamine B), remain close to the site of injection into a partial injury of the optic nerve, which is a central nervous system white matter tract.
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