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Aniruddha Ray, Yong-Eun Koo Lee, Gwangseong Kim and Raoul Kopelman Two-Photon Fluorescence Imaging Super-Enhanced by Multishell Nanophotonic Particles, with Application to Subcellular pH Small 8

Version of Record online: 20 APR 2012 | DOI: 10.1002/smll.201102664

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The two-photon fluorescence signal of a fluorophore is enhanced by utilizing the second harmonic of the exciting light generated by noble metal nanospheres in whose near-field dye molecules are placed. A multishell hydrogel nanoparticle containing a silver core, protective citrate capping, pH indicator dye, and polyacrylamide cladding is utilized for pH sensing and fluorescence imaging in live cells.

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