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Mark Platt, Geoff R. Willmott and Gil U. Lee Resistive Pulse Sensing of Analyte-Induced Multicomponent Rod Aggregation Using Tunable Pores Small 8

Version of Record online: 9 MAY 2012 | DOI: 10.1002/smll.201200058

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Tunable nanopores are used to monitor individual and aggregated rod-shaped nanoparticles as they move through a membrane opening. By controlling the surface chemistry and the location of the capture ligand, rods are made to form either long end-on-end or wide side-on aggregates upon the addition of an analyte. The potential of the assay is demonstrated for platelet-derived growth factor at sensitivities down to femtomolar levels.

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