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Parvesh Sharma, Niclas E. Bengtsson, Glenn A. Walter, Han-Byul Sohn, Guangyin Zhou, Nobutaka Iwakuma, Huadong Zeng, Stephen R. Grobmyer, Edward W. Scott and Brij M. Moudgil Gadolinium-Doped Silica Nanoparticles Encapsulating Indocyanine Green for Near Infrared and Magnetic Resonance Imaging Small 8

Version of Record online: 29 JUN 2012 | DOI: 10.1002/smll.201200258

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The development and functional evaluation (in vitro and in vivo) of biocompatible 25 nm silica nanoparticles encapsulating the only FDA-approved near infrared (NIR) organic dye, indocyanine green (ICG), and containing chelated paramagnetic gadolinium(III) is described. Prepared in one pot using microemulsions, the multimodal biocompatible nanoparticles allow non-invasive bioimaging by deep tissue optical imaging (NIR) and magnetic resonance imaging (MRI) simultaneously.

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