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Yuzhou Wu, Klaus Eisele, Mikheil Doroshenko, Gerardo Algara-Siller, Ute Kaiser, Kaloian Koynov and Tanja Weil A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging Small 8

Version of Record online: 23 AUG 2012 | DOI: 10.1002/smll.201200409

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Quantum dots (QDs) coated with an albumin-derived copolymer are positively charged, have attractive optical properties, and are noncytotoxic and stable in live cells. Their formation of a complex with plasmid DNA leads to proportionally decreased photoluminescence and facilitates efficient gene transfection, which is suitable for live-cell bioimaging and mechanistic studies of nonviral gene delivery.

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