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Noora Naghavi, Achala de Mel, Omid Sadeghi Alavijeh, Brian G. Cousins and Alexander M. Seifalian Nitric Oxide Donors for Cardiovascular Implant Applications Small 9

Version of Record online: 8 NOV 2012 | DOI: 10.1002/smll.201200458

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Small-diameter bypass grafts occlude in the absence of NO, resulting in platelet adhesion, smooth muscle cell (SMC) proliferation and migration from the site of anastomosis, causing repeat episodes of thrombosis and intimal hyperplasia leading to graft failure. The presence of NO-eluting micro- or nanoparticles within the vascular graft provides an environment similar to the natural vessel by inhibiting thrombus formation and SMC proliferation to prevent graft failure.

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