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Xinxin Zhao, Kimberly J. Ong, James D. Ede, James L. Stafford, Kee Woei Ng, Greg G. Goss and Say Chye Joachim Loo Evaluating the Toxicity of Hydroxyapatite Nanoparticles in Catfish Cells and Zebrafish Embryos Small 9

Version of Record online: 9 AUG 2012 | DOI: 10.1002/smll.201200639

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Hydroxyapatite nanoparticles (nHA) can delay zebrafish hatching. The hatching delay is related to particle concentration. nHA studied at the lowest concentration (3 μg mL−1) with hydrodynamic size of 394 nm causes the highest hatching inhibition at 72 hpf. Increased concentration induces microsize agglomeration, concomitant with low hatching inhibition.

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