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Junlong Geng, Kai Li, Dan Ding, Xinhai Zhang, Wei Qin, Jianzhao Liu, Ben Zhong Tang and Bin Liu Lipid-PEG-Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two-Photon Fluorescence Imaging Small 8

Article first published online: 15 AUG 2012 | DOI: 10.1002/smll.201200814

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Folic acid functionalized two-photon absorbing nanoparticles with aggregation induced emission characteristics are fabricated in a one-step procedure using a mixture of lipid-PEG-folate and lipid-PEG as the matrix. The obtained fluorescent nanoparticles show good biocompatibility and a large two photon absorption cross-section with far-red/near infrared fluorescence signature, which is ideal for live cell and animal imaging.

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