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Eric L. Kendall, Chenren Shao and Don L. DeVoe Visualizing the Growth and Dynamics of Liquid-Ordered Domains During Lipid Bilayer Folding in a Microfluidic Chip Small 8

Article first published online: 8 AUG 2012 | DOI: 10.1002/smll.201200831

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Using a novel lipid bubble injection technique, a microfluidic adaptation of Montal–Mueller bilayer folding is achieved in a thermoplastic chip supporting simultaneous optical and electrical monitoring and fluidic access to each membrane leaflet. The dynamic process of folding an asymmetric bilayer from two distinct lipid monolayersisprobed. The real-time emergence, movement, and coalescence of lipid microdomains is also investigated.

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