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Pranita Katwa, Xiaojia Wang, Rakhee N. Urankar, Ramakrishna Podila, Susana C. Hilderbrand, Robert B. Fick, Apparao M. Rao, Pu Chun Ke, Christopher J. Wingard and Jared M. Brown A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis Small 8

Article first published online: 6 JUL 2012 | DOI: 10.1002/smll.201200873

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The adverse pulmonary and cardiovascular responses elicited by multi-walled carbon nanotubes (MWCNTs) are mediated by IL-33 activation of mast cells via the ST2 receptor. MWCNT-induced toxicity is significantly decreased in the absence of mast cells, thus providing a potential therapeutic target for the adverse effects of nanoparticles.

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