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Srivani Veeranarayanan, Aby Cheruvathoor Poulose, M. Sheikh Mohamed, Saino Hanna Varghese, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa and D. Sakthi Kumar Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple-Targeted Dual-Drug Silica Nanoformulations for Theragnostics Small 8

Version of Record online: 3 AUG 2012 | DOI: 10.1002/smll.201200874

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A triple targeting scheme for nanodrug delivery simultaneously to cancer and angiogenesis is reported. This synergized multitarget concept culminates in elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency. The active targeted silica-based nanoformulation gains entry only into cancer and pathoangiogenic cells, sparing normal cells, whereas nontargeted nanoformulation shows nonspecific accumulation in both cancer and normal cells leading to normal cell damage.

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