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Jun Ge, Evgenios Neofytou, Jiandu Lei, Ramin E. Beygui and Richard N. Zare Protein–Polymer Hybrid Nanoparticles for Drug Delivery Small 8

Version of Record online: 9 AUG 2012 | DOI: 10.1002/smll.201200889

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Amphiphilic bovine serum albumin-poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self-assembling. Loaded with the hydrophobic anti-tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug.

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