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Sujin Yoon, Woo Jin Kim and Hyuk Sang Yoo Dual-Responsive Breakdown of Nanostructures with High Doxorubicin Payload for Apoptotic Anticancer Therapy Small 9

Version of Record online: 29 AUG 2012 | DOI: 10.1002/smll.201200997

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Doxorubicin (DOX) and oligodeoxynucleotide (ODN) are co-encapsulated in self-assembled nanoaggregates (NAs) for dual-responsive complete breakdown of the nanostructure. The release of DOX and ODN from ODN@DOX NAs is facilitated by glutathione reduction and the low pH in lysosomes and endosomes. ODN@DOX NAs show anticancer effects and the incorporated ODN and DOX synergistically induce apoptosis.

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