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Longhua Guo, Abdul Rahim Ferhan, Hailan Chen, Changming Li, Guonan Chen, Seungpyo Hong and Dong-Hwan Kim Distance-Mediated Plasmonic Dimers for Reusable Colorimetric Switches: A Measurable Peak Shift of More than 60 nm Small 9

Article first published online: 29 AUG 2012 | DOI: 10.1002/smll.201201061

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Real-time monitoring of a single-molecule binding event is demonstrated by a reconfigurable colorimetric DNA switch. A significant spectral shift of more than 60 nm is achievable from the target DNA binding. The extraordinary spectral shift allows the unaided eye to observe a single-target biomolecular binding event in real time using dark-field microscopy.

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