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Wen-Qing Li, Feng Wang, Zhi-Min Liu, Yu-Cai Wang, Jun Wang and Fei Sun Gold Nanoparticles Elevate Plasma Testosterone Levels in Male Mice without Affecting Fertility Small 9

Version of Record online: 22 AUG 2012 | DOI: 10.1002/smll.201201079

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ω-Methoxy and ω-aminoethyl poly(ethylene glycol)-modified 14-nm gold nanoparticles can accumulate in mouse testes, pass through the blood–testis barrier, and enter germ cells. Furthermore, PEG–NH2@AuNP accumulate more easier in the testes and increase plasma T levels. However, these two gold nanoparticle types have no effect on male fertility, fetal survival, or fetal development.

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