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Philip M. D. Severin and Hermann E. Gaub DNA–Protein Binding Force Chip Small 8

Article first published online: 9 AUG 2012 | DOI: 10.1002/smll.201201088

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The binding force chip (BiFo-Chip) allows the quantification of DNA–protein interactions. It employs arrays of molecular force probes. Each molecular force probe functions comparable to a balance, which is influenced by the binding of a protein to one of the two DNA duplexes. The BiFo-chip is easy to operate, requires only a quantitative fluorescence microscope and fulfills all essential criteria for high throughput screening.

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