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Weiqiang Chen, Yubing Sun and Jianping Fu Microfabricated Nanotopological Surfaces for Study of Adhesion-Dependent Cell Mechanosensitivity Small 9

Version of Record online: 7 AUG 2012 | DOI: 10.1002/smll.201201098

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A simple method for precise control and spatial patterning of local nanoroughness on glass surfaces is reported. Nanoroughness is a potent physical signal in the cell microenvironment to regulate cell functions, including cell morphology, adhesion, proliferation, and migration. Nanotopographic sensing by cells might involve integrin-mediated adhesion signaling and cytoskeletal contractility.

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