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Asmaa Elbakry, Eva-Christina Wurster, Alaa Zaky, Renate Liebl, Edith Schindler, Petra Bauer-Kreisel, Torsten Blunk, Reinhard Rachel, Achim Goepferich and Miriam Breunig Layer-by-Layer Coated Gold Nanoparticles: Size-Dependent Delivery of DNA into Cells Small 8

Version of Record online: 22 AUG 2012 | DOI: 10.1002/smll.201201112

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The cellular uptake of gold nanoparticles coated with poly(ethylene imine) and DNA in a layer-by-layer approach is explored. By tuning the size of the gold core, the number of nanoparticles and DNA molecules per cell can be controlled. Cytotoxicity studies show that poly(ethylene imine) can be applied at significantly higher concentration than its IC50 when bound to the nanoparticle surface.

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