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Beatriz Pelaz, Gaëlle Charron, Christian Pfeiffer, Yuliang Zhao, Jesus M. de la Fuente, Xing-Jie Liang, Wolfgang J. Parak and Pablo del Pino Interfacing Engineered Nanoparticles with Biological Systems: Anticipating Adverse Nano–Bio Interactions Small 9

Article first published online: 30 OCT 2012 | DOI: 10.1002/smll.201201229

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The biological fate of engineered nanoparticles (NPs) in physiological media is discussed. The four color-labeled scenarios illustrate (green) potential adverse effects following protein adsorption, (orange) functionalization of NPs with cell-penetrating peptides (CPPs) and antibodies (active targeting), (yellow) the possibility of ‘passivating’ NPs with suitable coatings, (blue) and adverse effects such as ‘NP dissolution’ and reactive oxygen species generation.

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