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Yun Zhao, Josephine L. C. Howe, Zhang Yu, David Tai Leong, Justin Jang Hann Chu, Joachim Say Chye Loo and Kee Woei Ng Exposure to Titanium Dioxide Nanoparticles Induces Autophagy in Primary Human Keratinocytes Small 9

Article first published online: 23 OCT 2012 | DOI: 10.1002/smll.201201363

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Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.

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