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Hariharasudhan D. Chirra and Tejal A. Desai Multi-Reservoir Bioadhesive Microdevices for Independent Rate-Controlled Delivery of Multiple Drugs Small 8

Article first published online: 7 SEP 2012 | DOI: 10.1002/smll.201201367

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Photolithography and reactive ion etching is used to fabricate microdevices with multiple reservoirs for oral drug delivery. Results show that the asymmetric shape of the device enhances the permeation of drugs across the epithelial layer via unidirectional release. The multiple reservoirs prove advantageous for releasing the multiple drugs independently. Bioadhesion is provided by surface-functionalized lectin.

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