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Guanghong Zuo, Seung-gu Kang, Peng Xiu, Yuliang Zhao and Ruhong Zhou Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level Small 9

Version of Record online: 5 OCT 2012 | DOI: 10.1002/smll.201201381

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Two potential molecular mechanisms have been proposed for carbon nanotubes’ inhibition of protein functions, one by disruption of the protein active sites, and the other by competitive binding with incoming ligands. The driving force is revealed to be dominated by the π–π stacking interaction.

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