Li Meng, Rui Chen, Aihua Jiang, Liming Wang, Peng Wang, Chen-zhong Li, Ru Bai, Yuliang Zhao, Herman Autrup and Chunying Chen Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway Small 9
The roles of the length of multiwall carbon nanotubes (MWCNTs) on neuronal differentiation of PC12 cells are investigated. Incubation of PC12 cells with carboxylated MWCNTs does not affect cellular morphology and viability at lower concentrations. Shorter MWCNTs show higher cellular uptake and more obvious exocytosis compared to longer ones, which can result in a higher ability to promote PC12 cell differentiation. Pre-incubation of short MWCNTs can up-regulate the expression of neurotrophin signaling pathway-associated TrkA/p75 receptors and Pincher/Gap43/TH proteins, which might be the underlying mechanism for the improved neuronal differentiation in PC12 cells.
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