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Xiaopin Duan and Yaping Li Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking Small 9

Version of Record online: 28 SEP 2012 | DOI: 10.1002/smll.201201390

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Multifunctional nanosystems that ensure not only long half-life, but also efficient internalization, are suitable for tumor-targeting delivery. Elongated particles coated with a hydrophilic polymer can selectively accumulate in tumors. After reaching tumor tissue, particles shift to spheres, and hydrophilic polymer is released to make particles hydrophobic, with ligand exposed on the surface facilitating internalization.

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