Kevin J. Freedman, Arangassery R. Bastian, Irwin Chaiken and Min Jun Kim Solid-State Nanopore Detection of Protein Complexes: Applications in Healthcare and Protein Kinetics Small 9
A nanopore platform is shown to detect various sub-populations of protein-protein complexes as well as dissociate freely translocating proteins generating unique current signatures. The proposed method of locally unbinding protein molecules allows enhancement of the specificity of diagnostic nanopore sensors as well as the abiltiy to study the recently unbound state of a protein. These applications underscore the label-free, inexpensive, electrical detection scheme offered by nanopore-based devices.
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