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Mustafa Hussain Kathawala, Sijing Xiong, Mark Richards, Kee Woei Ng, Saji George and Say Chye Joachim Loo Emerging In Vitro Models for Safety Screening of High-Volume Production Nanomaterials under Environmentally Relevant Exposure Conditions Small 9

Article first published online: 28 SEP 2012 | DOI: 10.1002/smll.201201452

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In vivo assessment on the safety of nanomaterials, though the gold standard, is extremely resource intensive, thus rendering this approach economically unviable. Conventional in vitro models, though fast and highly economical, do not perfectly mimic real-life situations. This review delves into emerging in vitro techniques that could bridge the gap between in vivo and in vivo studies, thereby balancing between resource usage and relevance to real-life situations.

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