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Jianquan Fan, Gang Fang, Fang Zeng, Xiaodan Wang and Shuizhu Wu Water-Dispersible Fullerene Aggregates as a Targeted Anticancer Prodrug with both Chemo- and Photodynamic Therapeutic Actions Small 9

Version of Record online: 1 NOV 2012 | DOI: 10.1002/smll.201201456

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Kill cancer cells with dual actions: A water-dispersible fullerene-aggregate-based Water-dispersible C60 aggregate based anticancer prodrug can selectively enter folic acid-positive cancer cells and kill them with both released drug and photodynamic therapeutic action under light irradiation. Thus enhanced cytotoxicity towards these cancer cells can be realized. The fluorescence quenching–restoring feature is utilized to track the intracellular drug release.

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