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Carolina Salvador-Morales, Pedro M. Valencia, Weiwei Gao, Rohit Karnik and Omid C. Farokhzad Spontaneous Formation of Heterogeneous Patches on Polymer–Lipid Core–Shell Particle Surfaces during Self-Assembly Small 9

Article first published online: 26 OCT 2012 | DOI: 10.1002/smll.201201499

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Spontaneous formation of heterogeneous patches on the surface of lipid-based nanoparticles (NPs) and microparticles (MPs) due to the segregation of two different functional groups. Patch formation is observed when tracing the functional groups with quantum dots, gold nanoparticles, and fluorescent dyes. This discovery could have important implications for the future design of self-assembled NPs and MPs for different biomedical applications.

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