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Vadim V. Sumbayev, Inna M. Yasinska, Cesar Pascual Garcia, Douglas Gilliland, Gurprit S. Lall, Bernhard F. Gibbs, David R. Bonsall, Luca Varani, François Rossi and Luigi Calzolai Gold Nanoparticles Downregulate Interleukin-1β-Induced Pro-Inflammatory Responses Small 9

Article first published online: 30 OCT 2012 | DOI: 10.1002/smll.201201528

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Interleukin 1 beta (IL-1β)-dependent inflammatory disorders pose a serious medical burden worldwide. Here it is shown for the first time that gold nanoparticles specifically downregulate cellular responses induced by IL-1β. These results indicate that the anti- inflammatory activity of gold nanoparticles is associated with an extracellular interaction with IL-1β, thus opening potentially novel options for further therapeutic applications.

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