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Sharon Waichman, Friedrich Roder, Christian P. Richter, Oliver Birkholz and Jacob Piehler Diffusion and Interaction Dynamics of Individual Membrane Protein Complexes Confined in Micropatterned Polymer-Supported Membranes Small 9

Version of Record online: 26 OCT 2012 | DOI: 10.1002/smll.201201530

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Micropatterned polymer-supported membranes based on photochemical coupling of hydrophobic tethers are established as a platform for functional reconstitution of transmembrane proteins. Thus, lateral motion within the membrane is possible, but confined within micrometer dimensions, enabling the simultaneous probing of diffusion and interaction dynamics of individual membrane protein complexes in a quantitative manner.

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