E-mail

E-mail a Wiley Online Library Link

Meng Li, Chuanqi Zhao, Xinjian Yang, Jinsong Ren, Can Xu and Xiaogang Qu In Situ Monitoring Alzheimer's Disease β-Amyloid Aggregation and Screening of Aβ Inhibitors Using a Perylene Probe Small 9

Article first published online: 14 SEP 2012 | DOI: 10.1002/smll.201201543

Thumbnail image of graphical abstract

A cationic perylene tetracarboxylic acid diimide derivative (1) is employed as a probe for in situ monitoring of Aβ aggregation and screening Aβ inhibitors. The assay is based on the fluorescence change through the aggregation of compound 1 following Aβ assembly. Importantly, this probe, compared with the well known amyloid-staining compound thioflavin T (ThT), is more sensitive to Aβ oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer's disease.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH