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Meng Li, Chuanqi Zhao, Xinjian Yang, Jinsong Ren, Can Xu and Xiaogang Qu In Situ Monitoring Alzheimer's Disease β-Amyloid Aggregation and Screening of Aβ Inhibitors Using a Perylene Probe Small 9

Article first published online: 14 SEP 2012 | DOI: 10.1002/smll.201201543

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A cationic perylene tetracarboxylic acid diimide derivative (1) is employed as a probe for in situ monitoring of Aβ aggregation and screening Aβ inhibitors. The assay is based on the fluorescence change through the aggregation of compound 1 following Aβ assembly. Importantly, this probe, compared with the well known amyloid-staining compound thioflavin T (ThT), is more sensitive to Aβ oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer's disease.

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