E-mail a Wiley Online Library Link

Alexey V. Tkach, Naveena Yanamala, Shyla Stanley, Michael R. Shurin, Galina V. Shurin, Elena R. Kisin, Ashley R. Murray, Samantha Pareso, Timur Khaliullin, Gregg P. Kotchey, Vincent Castranova, Sanjay Mathur, Bengt Fadeel, Alexander Star, Valerian E. Kagan and Anna A. Shvedova Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells Small 9

Article first published online: 13 AUG 2012 | DOI: 10.1002/smll.201201546

Thumbnail image of graphical abstract

Graphene oxide (GO) and C60- or C60-TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60-fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60-fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.