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Xuena Zhu, Evangelia Hondroulis, Wenjun Liu and Chen-zhong Li Biosensing Approaches for Rapid Genotoxicity and Cytotoxicity Assays upon Nanomaterial Exposure Small 9

Version of Record online: 18 FEB 2013 | DOI: 10.1002/smll.201201593

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Nanomaterials can enhance reactive oxygen species generation inside the human body, inducing oxidative stress, DNA damage, and unregulated cell signaling, and eventually leading to changes in cell motility, apoptosis, and even carcinogenesis. A novel lateral flow immunosensor is developed for rapid nanotoxicity assessment based on an oxidative DNA damage biomarker (8-hydroxy-2′-deoxyguanosine).

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