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Yarong Liu, Yun Fang, Yu Zhou, Ebrahim Zandi, Chi-Lin Lee, Kye-Il Joo and Pin Wang Site-Specific Modification of Adeno-Associated Viruses via a Genetically Engineered Aldehyde Tag Small 9

Version of Record online: 5 OCT 2012 | DOI: 10.1002/smll.201201661

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An aldehyde moiety can be genetically incorporated onto the capsid surface of adeno-associated viruses. This chemical handle can be selectively modified through bioorthogonal conjugation chemistry to functionally outfit virus coats with antibodies and peptides for targeted gene delivery, and labelling agents for imaging studies.

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