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Tarek R. Fadel, Nan Li, Smith Shah, Michael Look, Lisa D. Pfefferle, Gary L. Haller, Sune Justesen, Corey J. Wilson and Tarek M. Fahmy Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen-Specific T Cell Stimulation Small 9

Article first published online: 23 OCT 2012 | DOI: 10.1002/smll.201201684

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Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates (bCNTs). To overcome the denaturing effects of direct adsorption on bCNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.

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