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A. Gelmi, M. J. Higgins and G. G. Wallace Resolving Sub-Molecular Binding and Electrical Switching Mechanisms of Single Proteins at Electroactive Conducting Polymers Small 9

Article first published online: 17 OCT 2012 | DOI: 10.1002/smll.201201686

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An atomic force microscope (AFM) tip is functionalized with fibronectin protein and interacts with a conducting polymer electrode comprising a conjugated backbone with entrapped dopants such as chondroitin sulphate, hyaluronic acid, or dextran sulfate. The conducting polymer operates as the working electrode in a 3-electrode electrochemical cell, including auxiliary and reference electrodes, positioned under the AFM. Force spectroscopy measurements are performed as a function of an applied voltage to study biomolecular interactions under electrical control.

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