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Birgit Johanna Teubl, Claudia Meindl, Andreas Eitzlmayr, Andreas Zimmer, Eleonore Fröhlich and Eva Roblegg In-Vitro Permeability of Neutral Polystyrene Particles via Buccal Mucosa Small 9

Version of Record online: 30 OCT 2012 | DOI: 10.1002/smll.201201789

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In the buccal mucosa, the uptake of neutral polystyrene nanoparticles (PP) is size-dependent. Compared to 25 and 50 nm particles, 200 nm PP particles penetrate into deeper regions of the mucosa. This is attributed to the structure of the buccal mucosa, i.e., mucus layer and microplicae. The particles permeate the mucus layer and deposit in ridge-like folds of superficial buccal cells. Thus, the effects of thermodynamic driving forces and/or interparticle electrostatic repulsion are enhanced and cellular uptake might be reduced for smaller particle sizes.

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