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Rolando E. Yanes, Derrick Tarn, Angela A. Hwang, Daniel P. Ferris, Sean P. Sherman, Courtney R. Thomas, Jie Lu, April D. Pyle, Jeffrey I. Zink and Fuyuhiko Tamanoi Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition Small 9

Version of Record online: 14 NOV 2012 | DOI: 10.1002/smll.201201811

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The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.

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