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Katrin Vogel, Maximilian Glettenberg, Hendrik Schroeder and Christof M. Niemeyer DNA-Modification of Eukaryotic Cells Small 9

Version of Record online: 26 OCT 2012 | DOI: 10.1002/smll.201201852

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A novel bioorthogonal method for the modification of cells with single-stranded DNA oligomers is compared to alternative chemistries. The method based on oxime ligation offers high labeling efficacy, specificity, and mildness to avoid cell damage. DNA-modified cells can be selectively immobilized on solid supports or assembled into small cell clusters with the aid of DNA hybridization.

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