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Daniela Guarnieri, Annarita Falanga, Ornella Muscetti, Rossella Tarallo, Sabato Fusco, Massimiliano Galdiero, Stefania Galdiero and Paolo A. Netti Shuttle-Mediated Nanoparticle Delivery to the Blood–Brain Barrier Small 9

Article first published online: 7 NOV 2012 | DOI: 10.1002/smll.201201870

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The effect of a Herpes simplex type 1 viral fusion peptide (gH625) on brain endothelium uptake and crossing of fluorescent polystyrene nanoparticles and the underlying mechanism are described. This strategy may pave the way to design promising carriers for drug delivery across the brain for the treatment of central nervous system diseases.

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