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Chien-Liang Liu, Tzu-Ming Liu, Tsung-Yuan Hsieh, Han-Wen Liu, Yu-Shing Chen, Cheng-Kun Tsai, Hsieh-Chih Chen, Jong-Wei Lin, Ron-Bin Hsu, Tzung-Dau Wang, Chien-Cheng Chen, Chi-Kuang Sun and Pi-Tai Chou In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots Small 9

Version of Record online: 22 NOV 2012 | DOI: 10.1002/smll.201201887

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Functional human insulin–Au nanodots are synthesized for the in vivo imaging of insulin metabolism. In vivo investigations on mice ear and ex vivo assays on human fat tissues concluded that cells with rich insulin receptors have a higher uptake of administrated insulin. Therefore, human insulin–Au nanodots provide a new approach to explore subcellular insulin metabolism in model animals or patients with metabolic or cardiovascular diseases.

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